产品货号：
Z30019
中文名称：
YBX1抗体
英文名称：
Anti-YBX1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-YBX1 Antibody |
| 指标别名 | BP 8;CBF A;CSDA2;CSDB;DBPB;DNA binding protein B;EFI A;Enhancer factor I subunit A;MDR NF1;NSEP 1;NSEP1;Y box binding protein 1;Y box transcription factor;YB 1;YB1;YBX1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM |
| 基因名称 | YBX1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human YB1 (293-320aa ENPKPQDGKETKAADPPAENSSAPEAEQ),identical to the related mouse and rat sequences. |
| 实际分子量 | 50KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | YBX1(Y box binding protein 1),commonly referred to as "YB-1" by researchers,is a human protein.YB1 binding has an absolute requirement for the CCAAT box and relative specificity for the Y box.It has a molecular mass of 35,414 and contains 18% basic residues and putative nuclear localization signals.The YBX1 gene is mapped on 1p34.2.Ybx1 was highly expressed in mouse erythroid myeloid lymphoid clone-1 (EML),a hematopoietic precursor cell line,but that it was downregulated in myeloid progenitors and in Gmcsf-treated EML cells during myeloid differentiation.Ybx1 was expressed at high levels in myeloid leukemic cells at different developmental stages.Knockdown of YBX1 in a human leukemic cell line inhibited proliferation ability,induced apoptosis,and induced megakaryocytic differentiation in response to arsenic trioxide treatment.YBX1 is downregulated during myeloid differentiation and aberrant YBX1 expression in leukemic cells may contribute to leukemia development by blocking differentiation. |
| Uniprot ID | P67809 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | Y box binding protein 1 |
| 蛋白名全称 | Nuclease-sensitive element-binding protein 1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells |
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